Michael K Matheny,
Scientific Laboratory Manager
Department:
MD-POWELL GENE THERAPY CENTER
Business Phone:
(352) 273-8900
Business Email:
mathemk@ufl.edu
Publications
2023
Magnetic resonance quantification of skeletal muscle lipid infiltration in a humanized mouse model of Duchenne muscular dystrophy.
NMR in biomedicine.
36(3)
[DOI] 10.1002/nbm.4869.
[PMID] 36331178.
2021
Deletion of muscle Igf1 exacerbates disuse atrophy weakness in mice.
Journal of applied physiology (Bethesda, Md. : 1985).
131(3):881-894
[DOI] 10.1152/japplphysiol.00090.2021.
[PMID] 34292789.
2021
Filopodia powered by class x myosin promote fusion of mammalian myoblasts
Elife.
[DOI] 10.7554/eLife.72419; 10.7554/eLife.72419.sa1; 10.7554/eLife.72419.sa2.
2021
Filopodia powered by class x myosin promote fusion of mammalian myoblasts.
eLife.
10
[DOI] 10.7554/eLife.72419.
[PMID] 34519272.
2020
Glucocorticoids counteract hypertrophic effects of myostatin inhibition in dystrophic muscle.
JCI insight.
5(1)
[DOI] 10.1172/jci.insight.133276.
[PMID] 31830002.
2020
The D2.mdx mouse as a preclinical model of the skeletal muscle pathology associated with Duchenne muscular dystrophy.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-70987-y.
[PMID] 32826942.
2019
Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
33(1):181-194
[DOI] 10.1096/fj.201800459R.
[PMID] 29932867.
2018
Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.
Behavioural brain research.
340:14-22
[DOI] 10.1016/j.bbr.2017.04.025.
[PMID] 28419850.
2017
Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
42(1):59-67
[DOI] 10.1139/apnm-2016-0067.
[PMID] 28006433.
2017
Maternal Western Diet Age-Specifically Alters Female Offspring Voluntary Physical Activity and Dopamine- and Leptin-Related Gene Expression
The FASEB's Journal.
31(12):5371-5383
[DOI] 10.1096/fj.201700389R.
2017
The Building Blocks of Interoperability. A Multisite Analysis of Patient Demographic Attributes Available for Matching.
Applied clinical informatics.
8(2):322-336
[DOI] 10.4338/ACI-2016-11-RA-0196.
[PMID] 28378025.
2016
Anorexic response to rapamycin does not appear to involve a central mechanism.
Clinical and experimental pharmacology & physiology.
43(9):802-7
[DOI] 10.1111/1440-1681.12601.
[PMID] 27232670.
2016
High dietary fructose does not exacerbate the detrimental consequences of high fat diet on basilar artery function.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
67(2):205-16
[PMID] 27226180.
2016
Onset of leptin resistance shows temporal differences related to dose or pulsed treatment.
European journal of pharmacology.
779:177-85
[DOI] 10.1016/j.ejphar.2016.03.026.
[PMID] 27012992.
2016
Rapamycin Normalizes Serum Leptin by Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats.
The journals of gerontology. Series A, Biological sciences and medical sciences.
71(7):891-9
[DOI] 10.1093/gerona/glu230.
[PMID] 25617379.
2016
Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life
Journals of Gerontology Series A-Biological Sciences and Medical Sciences.
71(7):866-875
[DOI] 10.1093/gerona/glu238.
[PMID] 25617380.
2014
Drugs and Devices: Challenges and Opportunities for the Evaluation of Combination Medical Products
Pharmacoepidemiology and Drug Safety.
23(1, SI)
2014
Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia.
Journal of immunology (Baltimore, Md. : 1950).
192(12):6111-9
[DOI] 10.4049/jimmunol.1302895.
[PMID] 24829407.
2014
Targeted leptin receptor blockade: role of ventral tegmental area and nucleus of the solitary tract leptin receptors in body weight homeostasis.
The Journal of endocrinology.
222(1):27-41
[DOI] 10.1530/JOE-13-0455.
[PMID] 24920667.
2013
Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes.
Neuropharmacology.
65:90-100
[DOI] 10.1016/j.neuropharm.2012.09.005.
[PMID] 22982569.
2012
Simultaneous introduction of a novel high fat diet and wheel running induces anorexia.
Physiology & behavior.
105(4):909-14
[DOI] 10.1016/j.physbeh.2011.11.011.
[PMID] 22115947.
2011
POMC overexpression in the ventral tegmental area ameliorates dietary obesity.
The Journal of endocrinology.
210(2):199-207
[DOI] 10.1530/JOE-10-0418.
[PMID] 21565854.
2011
Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats.
Neuropharmacology.
60(2-3):480-7
[DOI] 10.1016/j.neuropharm.2010.11.002.
[PMID] 21059361.
2010
Wheel running eliminates high-fat preference and enhances leptin signaling in the ventral tegmental area.
Physiology & behavior.
100(2):173-9
[DOI] 10.1016/j.physbeh.2010.02.017.
[PMID] 20193697.
2009
Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis.
American journal of physiology. Regulatory, integrative and comparative physiology.
297(5):R1254-61
[DOI] 10.1152/ajpregu.90449.2008.
[PMID] 19726711.
2008
Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats.
Diabetes.
57(3):614-22
[PMID] 18086903.
2007
Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance.
The Journal of pharmacology and experimental therapeutics.
320(2):706-12
[PMID] 17082312.
2007
Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent.
American journal of physiology. Regulatory, integrative and comparative physiology.
292(2):R868-74
[PMID] 17023670.
2007
Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension.
Journal of hypertension.
25(12):2471-8
[PMID] 17984669.
2007
Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss.
American journal of physiology. Endocrinology and metabolism.
293(1):E252-8
[PMID] 17389713.
2006
Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity.
Neurobiology of aging.
27(3):459-70
[PMID] 15964099.
2006
Oral vanadium enhances the catabolic effects of central leptin in young adult rats.
Endocrinology.
147(1):493-501
[PMID] 16195403.
2005
Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats.
Diabetologia.
48(6):1075-83
[PMID] 15864530.
2003
Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II.
Neuropharmacology.
45(2):211-9
[PMID] 12842127.
2002
Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses.
Gene therapy.
9(22):1492-9
[PMID] 12407421.
2002
Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats.
Neuroscience.
115(3):879-89
[PMID] 12435426.
2002
Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance.
Endocrinology.
143(8):3026-35
[PMID] 12130569.
2001
Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats.
Neuroscience.
104(4):1111-7
[PMID] 11457594.
2000
Impaired leptin responsiveness in aged rats.
Diabetes.
49(3):431-5
[PMID] 10868965.
2000
Impaired leptin signal transduction with age-related obesity.
Neuropharmacology.
39(10):1872-9
[PMID] 10884568.
2000
Modulation of uncoupling protein 2 and uncoupling protein 3: regulation by denervation, leptin and retinoic acid treatment.
The Journal of endocrinology.
164(3):331-7
[PMID] 10694373.
1999
Differential down-regulation of beta3-adrenergic receptor mRNA and signal transduction by cold exposure in brown adipose tissue of young and senescent rats.
Pflugers Archiv-European Journal of Physiology.
437(3):479-83
[DOI] 10.1007/s004240050804.
[PMID] 9914406.
1997
Leptin gene expression increases with age independent of increasing adiposity in rats.
Diabetes.
46(12):2035-9
[PMID] 9392492.
Contact Details
Phones:
- Business:
- (352) 273-8900
Emails:
- Business:
- mathemk@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100292
GAINESVILLE FL 32610 - Business Street:
-
RG-171A
GAINESVILLE FL 32611