AAV Capsids Developed at the University of Florida
| AAV serotype/variant | Capsid mutations | Cell tropism | References |
|---|---|---|---|
| AAV1 | — | RPE, Muscle | Burger et al. |
| AAV2 | — | Liver, RPE, RGC | Acland et al.; Guy et al. |
| AAV2 (444) | Y444F | Liver, RPE, RGC, TM | Petrs-Silva et al.; Bogner et al. |
| AAV2 (double) | Y444F, Y730F | RPE, RGC | Petrs-Silva et al. |
| AAV2 (triple) | Y444F+Y500F+Y730F | Liver, brain, RGC, PR | Petrs-Silva et al. |
| AAV2 (quad) | Y272F+Y444F+Y500F+Y730F | RGC, PR, VEC | Petrs-Silva et al.; Cai et al. |
| AAV2 (quadY-F)+T-V | Y272F+Y444F+Y500F+Y730F+T491V | RGC, BP, VEC | Kay et al.; Scalabrino et al.; Boyd et al. |
| AAV2 (4pMut) | Y444F+Y500F+Y730F+T491V | Liver, RGC, PR | Boye et al.; Boyd et al. |
| AAV2 (4pMut)ΔHS | — | Brain, PR, RPE | Boye et. al. |
| AAV5 | — | PR, RPE, Cornea, Brain | Boye et al.; Beltran et al.; Mohan et al.; Burger et al. |
| AAV5 (719) | Y719F | PR, RPE | Michalakis et al. |
| AAV6 | — | HSCs, glia | Song et al. |
| AAV6 (triple) | Y705+731F+T492V | HSCs, glia | Rosario et al. |
| AAV8 | — | PR | Allocca et al. |
| AAV8 (447) | Y447F | PR | Petrs-Silva et al. |
| AAV8 (733) | Y733F | PR, RPE | Petrs-Silva et al.; Pang et al.; Boye et al., Deng et al. |
| AAV8(doubleYF) | Y447F+Y733F) | PR | Kay et al. |
| AAV8 (doubleYF+T-V) | Y447F+Y733F+T494V) | PR, Brain | Kay et al. |
| AAV9 | — | PR, Liver, Heart | Lebherz et al.; Sarkar et al. |