David Fuller

David Fuller,

Professor

Department: HP-PHYSICAL THERAPY
Business Phone: (352) 273-6634
Business Email: dfuller@phhp.ufl.edu

About David Fuller

My research laboratory in the UF McKnight Brain Institute is funded by multiple NIH grants. Current areas of emphasis include 1) electrical, pharmacological, and chemogenetic stimulation of spinal neurons to promote respiratory motor recovery after spinal cord injury; 2) therapeutic uses of oxygen in neurodegenerative diseases, and 3) understanding the control of breathing in Pompe disease, and testing gene therapy approaches for this disorder.

I serve as PI of an NIH T32 Training Grant https://pt.phhp.ufl.edu/train-with-us/t-32/. This T32 training program in Neuromuscular Plasticity has been continually funded for 20 years, and provides interdisciplinary training of clinicians and basic scientists in neuromuscular plasticity and rehabilitation science.

I also serve as Director of the Rehabilitation Science Doctoral Program (RSD). Offered through the College of Public Health and Health Professions, this is one of the largest rehabilitation science programs in the country. The RSD program is designed to prepare students with clinical (including DPT, OT, SLP, and MD) or basic science backgrounds for careers as rehabilitation researchers. Students develop skills in research, teaching and interdisciplinary teamwork.

Lastly, I am the Associate Director of the Breathing Research and Therapeutics Center (BREATHE). https://breathe.phhp.ufl.edu/. BREATHE brings researchers together from throughout the UF campus in a collaborative effort to advance the understanding and treatment of neuromuscular disorders that compromise breathing.

Additional Positions:
Director, NIH T32 Training Program: Neuromuscular Plasticity and Rehabilitation
2016 – Current · University of Florida
Director, Rehabilitation Science PhD Program
2015 – Current · University of Florida
Associate Director, Breathing Research and Therapeutics (BREATHE) Center
2015 – Current · University of Florida

Teaching Profile

Courses Taught
2008-2011,2013-2021,2015-2021,2020-2021
RSD6905 Individual Work
2008,2010-2016,2016-2021,2020-2021
RSD6910 Supervised Research
2008-2014,2016-2022
RSD7979 Advanced Research
2010-2016,2018-2025
RSD7980 Research for Doctoral Dissertation
2018,2020-2023
RSD6718 Neuroplasticity: A Foundation for Neurorehabilitation
2018,2023-2025
GMS7980 Research for Doctoral Dissertation
2006-2010,2016-2018
PHT6168C Neurosci Phys Therapy
2018
BME7980 Research for Doctoral Dissertation
2018
PHT6152C Exercise Physiology
2009,2016-2017
RSD6940 Supervised Teaching
2007,2009-2012,2012-2016,2014-2016,2016
PHT6718 Neuroplasticity
2013-2015
PHT6153 Physiology for Pt
2014
GMS7794 Neuroscience Seminar
2014
HSC4913 Supervised Research Experience
2008,2010-2013
PHT6935C Seminar
2011-2013
HSC4905 Individual Study
2008,2012-2024,2024
HSC4970 Public Health and Health Professions Senior Honors Thesis
2022-2023
GMS6905 Independent Studies in Medical Sciences
2022-2023
GMS6701 Functional and Comparative Neuroanatomy for Professionals
2023-2025
GMS7979 Advanced Research
2023
GMS6090 Research in Medical Sciences
2023
GMS7795 Special Topics in Neuroscience
2024-2025
GMS6971 Research for Master’s Thesis

Research Profile

The focus of my research is respiratory neuromuscular control and rehabilitation. Current areas of emphasis include 1) developing gene therapy approaches for respiratory neuromuscular disorders, 2) electrical, pharmacological, and chemogenetic stimulation of respiratory neurons to promote respiratory motor recovery after spinal cord injury, and 3) therapeutic uses of oxygen following spinal cord injury.

Open Researcher and Contributor ID (ORCID)

0000-0001-5013-5972

Publications

2024
Acute ampakines increase voiding function and coordination in a rat model of SCI.
eLife. 12 [DOI] 10.7554/eLife.89767. [PMID] 38451184.
2024
AMPA receptors play an important role in the biological consequences of spinal cord injury: Implications for AMPA receptor modulators for therapeutic benefit.
Biochemical pharmacology. [DOI] 10.1016/j.bcp.2024.116302. [PMID] 38763261.
2024
Ampakines increase diaphragm activation following mid-cervical contusion injury in rats.
Experimental neurology. 376 [DOI] 10.1016/j.expneurol.2024.114769. [PMID] 38582278.
2024
Author Response: Acute ampakines increase voiding function and coordination in a rat model of SCI
. [DOI] 10.7554/elife.89767.2.sa4.
2024
Chemogenetic stimulation of phrenic motor output and diaphragm activity.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.04.12.589188. [PMID] 38659846.
2024
Pattern sensitivity of ampakine-hypoxia interactions for evoking phrenic motor facilitation in anesthetized rat
Journal of Neurophysiology. 131(2):216-224 [DOI] 10.1152/jn.00315.2023.
2023
Acute ampakines increase voiding function and coordination in a rat model of SCI.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.05.26.542339. [PMID] 37293023.
2023
Breathing patterns and CO2 production in adult spiny mice (Acomys cahirinus).
Respiratory physiology & neurobiology. 307 [DOI] 10.1016/j.resp.2022.103975. [PMID] 36206972.
2023
Current avenues of gene therapy in Pompe disease.
Current opinion in neurology. 36(5):464-473 [DOI] 10.1097/WCO.0000000000001187. [PMID] 37639402.
2023
Diaphragm pacing and independent breathing in individuals with severe Pompe disease.
Frontiers in rehabilitation sciences. 4 [DOI] 10.3389/fresc.2023.1184031. [PMID] 37583873.
2023
Optogenetic activation of the tongue in spontaneously breathing mice.
Respiratory physiology & neurobiology. 309 [DOI] 10.1016/j.resp.2022.103998. [PMID] 36423822.
2023
Optogenetic activation of the tongue in spontaneously breathing mice.
Respiratory physiology & neurobiology. 309 [DOI] 10.1016/j.resp.2022.103998. [PMID] 36423822.
2023
Oxygen therapy attenuates neuroinflammation after spinal cord injury.
Journal of neuroinflammation. 20(1) [DOI] 10.1186/s12974-023-02985-6. [PMID] 38110993.
2023
Targeting drug or gene delivery to the phrenic motoneuron pool
Journal of Neurophysiology. 129(1):144-158 [DOI] 10.1152/jn.00432.2022. [PMID] 36416447.
2023
Targeting drug or gene delivery to the phrenic motoneuron pool.
Journal of neurophysiology. 129(1):144-158 [DOI] 10.1152/jn.00432.2022. [PMID] 36416447.
2023
Uman-type neurofilament light antibodies are effective reagents for the imaging of neurodegeneration.
Brain communications. 5(2) [DOI] 10.1093/braincomms/fcad067. [PMID] 37091583.
2023
Uman-type neurofilament light antibodies are effective reagents for the imaging of neurodegeneration.
Brain communications. 5(2) [DOI] 10.1093/braincomms/fcad067. [PMID] 37091583.
2022
Chemogenetic activation of hypoglossal motoneurons in a mouse model of Pompe disease
Journal of Neurophysiology. 128(5):1133-1142 [DOI] 10.1152/jn.00026.2022. [PMID] 35976060.
2022
Effects of Hyperbaric Oxygen Preconditioning on Doxorubicin Cardiorespiratory Toxicity.
Antioxidants (Basel, Switzerland). 11(10) [DOI] 10.3390/antiox11102073. [PMID] 36290796.
2022
Enhancing Locomotor Learning With Transcutaneous Spinal Electrical Stimulation and Somatosensory Augmentation: A Pilot Randomized Controlled Trial in Older Adults.
Frontiers in aging neuroscience. 14 [DOI] 10.3389/fnagi.2022.837467. [PMID] 35309891.
2022
Feasibility of transcutaneous spinal direct current stimulation combined with locomotor training after spinal cord injury.
Spinal cord. 60(11):971-977 [DOI] 10.1038/s41393-022-00801-1. [PMID] 35477745.
2022
Hyperbaric Oxygen Therapy after Mid-Cervical Spinal Contusion Injury.
Journal of neurotrauma. 39(9-10):715-723 [DOI] 10.1089/neu.2021.0412. [PMID] 35152735.
2022
Hyperbaric Oxygen Therapy after Mid-Cervical Spinal Contusion Injury.
Journal of neurotrauma. 39(9-10):715-723 [DOI] 10.1089/neu.2021.0412. [PMID] 35152735.
2022
Locomotor-respiratory coupling in ambulatory adults with incomplete spinal cord injury.
Spinal cord series and cases. 8(1) [DOI] 10.1038/s41394-022-00515-9. [PMID] 35501342.
2022
Locomotor-respiratory coupling in ambulatory adults with incomplete spinal cord injury.
Spinal cord series and cases. 8(1) [DOI] 10.1038/s41394-022-00515-9. [PMID] 35501342.
2022
Optogenetic activation of the diaphragm.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-10240-w. [PMID] 35444167.
2022
Optogenetic activation of the diaphragm.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-10240-w. [PMID] 35444167.
2022
Spinally delivered ampakine CX717 increases phrenic motor output in adult rats
Respiratory Physiology & Neurobiology. 296 [DOI] 10.1016/j.resp.2021.103814. [PMID] 34775071.
2022
The phrenic neuromuscular system.
Handbook of clinical neurology. 188:393-408 [DOI] 10.1016/B978-0-323-91534-2.00012-6. [PMID] 35965035.
2022
The phrenic neuromuscular system.
Handbook of clinical neurology. 188:393-408 [DOI] 10.1016/B978-0-323-91534-2.00012-6. [PMID] 35965035.
2021
Ampakine pretreatment enables a single hypoxic episode to produce phrenic motor facilitation with no added benefit of additional episodes.
Journal of neurophysiology. 126(4):1420-1429 [DOI] 10.1152/jn.00307.2021. [PMID] 34495779.
2021
Ampakine pretreatment enables a single hypoxic episode to produce phrenic motor facilitation with no added benefit of additional episodes.
Journal of neurophysiology. 126(4):1420-1429 [DOI] 10.1152/jn.00307.2021. [PMID] 34495779.
2021
Ampakines Stimulate Diaphragm Activity after Spinal Cord Injury.
Journal of neurotrauma. 38(24):3467-3482 [DOI] 10.1089/neu.2021.0301. [PMID] 34806433.
2021
Ampakines Stimulate Diaphragm Activity after Spinal Cord Injury.
Journal of neurotrauma. 38(24):3467-3482 [DOI] 10.1089/neu.2021.0301. [PMID] 34806433.
2021
Automated Classification of Whole Body Plethysmography Waveforms to Quantify Breathing Patterns.
Frontiers in physiology. 12 [DOI] 10.3389/fphys.2021.690265. [PMID] 34489719.
2021
Automated Classification of Whole Body Plethysmography Waveforms to Quantify Breathing Patterns.
Frontiers in physiology. 12 [DOI] 10.3389/fphys.2021.690265. [PMID] 34489719.
2021
Case Studies in Neuroscience: Neuropathology and diaphragm dysfunction in ventilatory failure from late-onset Pompe disease.
Journal of neurophysiology. 126(2):351-360 [DOI] 10.1152/jn.00190.2021. [PMID] 34191636.
2021
Case Studies in Neuroscience: Neuropathology and diaphragm dysfunction in ventilatory failure from late-onset Pompe disease.
Journal of neurophysiology. 126(2):351-360 [DOI] 10.1152/jn.00190.2021. [PMID] 34191636.
2021
Designer Receptors Exclusively Activated by Designer Drugs Approach to Treatment of Sleep-disordered Breathing.
American journal of respiratory and critical care medicine. 203(1):102-110 [DOI] 10.1164/rccm.202002-0321OC. [PMID] 32673075.
2021
Designer Receptors Exclusively Activated by Designer Drugs Approach to Treatment of Sleep-disordered Breathing.
American journal of respiratory and critical care medicine. 203(1):102-110 [DOI] 10.1164/rccm.202002-0321OC. [PMID] 32673075.
2021
Diaphragm Pacing and a Model for Respiratory Rehabilitation After Spinal Cord Injury.
Journal of neurologic physical therapy : JNPT. 45(3):235-242 [DOI] 10.1097/NPT.0000000000000360. [PMID] 34049339.
2021
Diaphragm Pacing and a Model for Respiratory Rehabilitation After Spinal Cord Injury.
Journal of neurologic physical therapy : JNPT. 45(3):235-242 [DOI] 10.1097/NPT.0000000000000360. [PMID] 34049339.
2021
Gene delivery to the hypoglossal motor system: preclinical studies and translational potential
Gene Therapy. 28(7-8):402-412 [DOI] 10.1038/s41434-021-00225-1. [PMID] 33574581.
2021
Gene delivery to the hypoglossal motor system: preclinical studies and translational potential.
Gene therapy. 28(7-8):402-412 [DOI] 10.1038/s41434-021-00225-1. [PMID] 33574581.
2021
Phrenic afferent activation modulates cardiorespiratory output in the adult rat.
Journal of neurophysiology. 126(6):2091-2103 [DOI] 10.1152/jn.00433.2021. [PMID] 34788165.
2021
Phrenic afferent activation modulates cardiorespiratory output in the adult rat.
Journal of neurophysiology. 126(6):2091-2103 [DOI] 10.1152/jn.00433.2021. [PMID] 34788165.
2021
Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation
Communications Biology. 4(1) [DOI] 10.1038/s42003-020-01604-x. [PMID] 33495588.
2021
Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation.
Communications biology. 4(1) [DOI] 10.1038/s42003-020-01604-x. [PMID] 33495588.
2021
Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury.
Experimental neurology. 342 [DOI] 10.1016/j.expneurol.2021.113735. [PMID] 33951477.
2021
Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury.
Experimental neurology. 342 [DOI] 10.1016/j.expneurol.2021.113735. [PMID] 33951477.
2021
Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
npj Regenerative Medicine. 6(1) [DOI] 10.1038/s41536-020-00111-1. [PMID] 33397999.
2021
Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin.
NPJ Regenerative medicine. 6(1) [DOI] 10.1038/s41536-020-00111-1. [PMID] 33397999.
2020
Advancements in AAV-mediated Gene Therapy for Pompe Disease.
Journal of neuromuscular diseases. 7(1):15-31 [DOI] 10.3233/JND-190426. [PMID] 31796685.
2020
Advancements in AAV-mediated Gene Therapy for Pompe Disease.
Journal of neuromuscular diseases. 7(1):15-31 [DOI] 10.3233/JND-190426. [PMID] 31796685.
2020
Ampakine pretreatment enables a single brief hypoxic episode to evoke phrenic motor facilitation.
Journal of neurophysiology. 123(3):993-1003 [DOI] 10.1152/jn.00708.2019. [PMID] 31940229.
2020
Ampakine pretreatment enables a single brief hypoxic episode to evoke phrenic motor facilitation.
Journal of neurophysiology. 123(3):993-1003 [DOI] 10.1152/jn.00708.2019. [PMID] 31940229.
2020
Ampakines stimulate phrenic motor output after cervical spinal cord injury
Experimental Neurology. 334 [DOI] 10.1016/j.expneurol.2020.113465. [PMID] 32949571.
2020
Ampakines stimulate phrenic motor output after cervical spinal cord injury.
Experimental neurology. 334 [DOI] 10.1016/j.expneurol.2020.113465. [PMID] 32949571.
2020
Autonomous control of ventilation through closed-loop adaptive respiratory pacing.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-78834-w. [PMID] 33318547.
2020
Autonomous control of ventilation through closed-loop adaptive respiratory pacing.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-78834-w. [PMID] 33318547.
2020
Cover Image, Volume 528, Issue 9
Journal of Comparative Neurology. 528(9) [DOI] 10.1002/cne.24915.
2020
Hyperbaric Oxygen Treatment Following Mid-Cervical Spinal Cord Injury Preserves Diaphragm Muscle Function.
International journal of molecular sciences. 21(19) [DOI] 10.3390/ijms21197219. [PMID] 33007822.
2020
Hyperbaric Oxygen Treatment Following Mid-Cervical Spinal Cord Injury Preserves Diaphragm Muscle Function.
International journal of molecular sciences. 21(19) [DOI] 10.3390/ijms21197219. [PMID] 33007822.
2020
Mid-cervical interneuron networks following high cervical spinal cord injury.
Respiratory physiology & neurobiology. 271 [DOI] 10.1016/j.resp.2019.103305. [PMID] 31553921.
2020
Mid-cervical interneuron networks following high cervical spinal cord injury.
Respiratory physiology & neurobiology. 271 [DOI] 10.1016/j.resp.2019.103305. [PMID] 31553921.
2020
Molecular and histologic outcomes following spinal cord injury in spiny mice, Acomys cahirinus
Journal of Comparative Neurology. 528(9):1535-1547 [DOI] 10.1002/cne.24836. [PMID] 31820438.
2020
Molecular and histologic outcomes following spinal cord injury in spiny mice, Acomys cahirinus.
The Journal of comparative neurology. 528(9):1535-1547 [DOI] 10.1002/cne.24836. [PMID] 31820438.
2020
Pharmacological targeting of mitochondrial function and reactive oxygen species production prevents colon 26 cancer-induced cardiorespiratory muscle weakness.
Oncotarget. 11(38):3502-3514 [DOI] 10.18632/oncotarget.27748. [PMID] 33014286.
2020
Pharmacological targeting of mitochondrial function and reactive oxygen species production prevents colon 26 cancer-induced cardiorespiratory muscle weakness.
Oncotarget. 11(38):3502-3514 [DOI] 10.18632/oncotarget.27748. [PMID] 33014286.
2020
Respiratory resetting elicited by single pulse spinal stimulation.
Respiratory physiology & neurobiology. 274 [DOI] 10.1016/j.resp.2019.103339. [PMID] 31734416.
2020
Respiratory resetting elicited by single pulse spinal stimulation.
Respiratory physiology & neurobiology. 274 [DOI] 10.1016/j.resp.2019.103339. [PMID] 31734416.
2020
Targeted activation of spinal respiratory neural circuits.
Experimental neurology. 328 [DOI] 10.1016/j.expneurol.2020.113256. [PMID] 32087253.
2020
Targeted activation of spinal respiratory neural circuits.
Experimental neurology. 328 [DOI] 10.1016/j.expneurol.2020.113256. [PMID] 32087253.
2019
A geometric framework for ensemble average propagator reconstruction from diffusion MRI.
Medical image analysis. 57:89-105 [DOI] 10.1016/j.media.2019.06.012. [PMID] 31295681.
2019
A geometric framework for ensemble average propagator reconstruction from diffusion MRI.
Medical image analysis. 57:89-105 [DOI] 10.1016/j.media.2019.06.012. [PMID] 31295681.
2019
AAV Gene Therapy Utilizing Glycosylation-Independent Lysosomal Targeting Tagged GAA in the Hypoglossal Motor System of Pompe Mice.
Molecular therapy. Methods & clinical development. 15:194-203 [DOI] 10.1016/j.omtm.2019.08.009. [PMID] 31660421.
2019
AAV Gene Therapy Utilizing Glycosylation-Independent Lysosomal Targeting Tagged GAA in the Hypoglossal Motor System of Pompe Mice.
Molecular therapy. Methods & clinical development. 15:194-203 [DOI] 10.1016/j.omtm.2019.08.009. [PMID] 31660421.
2019
Cancer cachexia impairs neural respiratory drive in hypoxia but not hypercapnia.
Journal of cachexia, sarcopenia and muscle. 10(1):63-72 [DOI] 10.1002/jcsm.12348. [PMID] 30362273.
2019
Cancer cachexia impairs neural respiratory drive in hypoxia but not hypercapnia.
Journal of cachexia, sarcopenia and muscle. 10(1):63-72 [DOI] 10.1002/jcsm.12348. [PMID] 30362273.
2019
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy.
Annals of translational medicine. 7(13) [DOI] 10.21037/atm.2019.05.56. [PMID] 31392202.
2019
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy.
Annals of translational medicine. 7(13) [DOI] 10.21037/atm.2019.05.56. [PMID] 31392202.
2018
How does spinal cord injury lead to obstructive sleep apnoea?
The Journal of Physiology. 596(14):2633-2633 [DOI] 10.1113/jp276162.
2018
Injectable hydrogels of optimized acellular nerve for injection in the injured spinal cord.
Biomedical materials (Bristol, England). 13(3) [DOI] 10.1088/1748-605X/aaab82. [PMID] 29380749.
2018
Intraspinal microstimulation for respiratory muscle activation.
Experimental neurology. 302:93-103 [DOI] 10.1016/j.expneurol.2017.12.014. [PMID] 29305050.
2018
Pharmacological modulation of hypoxia-induced respiratory neuroplasticity.
Respiratory physiology & neurobiology. 256:4-14 [DOI] 10.1016/j.resp.2017.11.008. [PMID] 29197629.
2018
Pharmacological modulation of hypoxia-induced respiratory neuroplasticity.
Respiratory physiology & neurobiology. 256:4-14 [DOI] 10.1016/j.resp.2017.11.008. [PMID] 29197629.
2017
Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice.
American journal of physiology. Lung cellular and molecular physiology. 312(6):L873-L881 [DOI] 10.1152/ajplung.00568.2016. [PMID] 28336814.
2017
Anatomy and physiology of phrenic afferent neurons.
Journal of neurophysiology. 118(6):2975-2990 [DOI] 10.1152/jn.00484.2017. [PMID] 28835527.
2017
Automated Gait Analysis Through Hues and Areas (AGATHA): A Method to Characterize the Spatiotemporal Pattern of Rat Gait.
Annals of biomedical engineering. 45(3):711-725 [DOI] 10.1007/s10439-016-1717-0. [PMID] 27554674.
2017
Coupling multielectrode array recordings with silver labeling of recording sites to study cervical spinal network connectivity.
Journal of neurophysiology. 117(3):1014-1029 [DOI] 10.1152/jn.00638.2016. [PMID] 27974450.
2017
High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury.
Journal of neurophysiology. 118(4):2344-2357 [DOI] 10.1152/jn.00913.2016. [PMID] 28615341.
2017
Histological identification of phrenic afferent projections to the spinal cord.
Respiratory physiology & neurobiology. 236:57-68 [DOI] 10.1016/j.resp.2016.11.006. [PMID] 27838334.
2017
Intermittent Hypoxia Enhances Functional Connectivity of Midcervical Spinal Interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(35):8349-8362 [DOI] 10.1523/JNEUROSCI.0992-17.2017. [PMID] 28751456.
2017
Intraspinal microstimulation and diaphragm activation after cervical spinal cord injury.
Journal of neurophysiology. 117(2):767-776 [DOI] 10.1152/jn.00721.2016. [PMID] 27881723.
2017
Intraspinal transplantation of subventricular zone-derived neural progenitor cells improves phrenic motor output after high cervical spinal cord injury.
Experimental neurology. 287(Pt 2):205-215 [DOI] 10.1016/j.expneurol.2016.06.007. [PMID] 27302679.
2017
Respiratory neuroplasticity – Overview, significance and future directions.
Experimental neurology. 287(Pt 2):144-152 [DOI] 10.1016/j.expneurol.2016.05.022. [PMID] 27208699.
2017
Safety of Intradiaphragmatic Delivery of Adeno-Associated Virus-Mediated Alpha-Glucosidase (rAAV1-CMV-hGAA) Gene Therapy in Children Affected by Pompe Disease.
Human gene therapy. Clinical development. 28(4):208-218 [DOI] 10.1089/humc.2017.146. [PMID] 29160099.
2017
Special Issue: Respiratory Neuroplasticity.
Experimental neurology. 287(Pt 2):91-92 [DOI] 10.1016/j.expneurol.2016.11.004. [PMID] 27871363.
2017
Spinal decision making for respiratory muscle recruitment?
The Journal of Physiology. 595(23):7017-7017 [DOI] 10.1113/jp275225.
2016
Altered activation of the diaphragm in late-onset Pompe disease.
Respiratory physiology & neurobiology. 222:11-5 [DOI] 10.1016/j.resp.2015.11.013. [PMID] 26612101.
2016
Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation.
Journal of neurophysiology. 116(3):1232-8 [DOI] 10.1152/jn.00210.2016. [PMID] 27306673.
2016
Cervical spinal cord injury exacerbates ventilator-induced diaphragm dysfunction.
Journal of applied physiology (Bethesda, Md. : 1985). 120(2):166-77 [DOI] 10.1152/japplphysiol.00488.2015. [PMID] 26472866.
2016
Diaphragm Pacing as a Rehabilitative Tool for Patients With Pompe Disease Who Are Ventilator-Dependent: Case Series.
Physical therapy. 96(5):696-703 [DOI] 10.2522/ptj.20150122. [PMID] 26893511.
2016
Forelimb muscle plasticity following unilateral cervical spinal cord injury.
Muscle & nerve. 53(3):475-8 [DOI] 10.1002/mus.25007. [PMID] 26662579.
2016
Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep.
Sleep. 39(5):1097-106 [DOI] 10.5665/sleep.5762. [PMID] 26951402.
2016
Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice.
Respiratory physiology & neurobiology. 227:48-55 [DOI] 10.1016/j.resp.2016.02.007. [PMID] 26921786.
2016
Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice.
Journal of neurophysiology. 115(3):1372-80 [DOI] 10.1152/jn.00479.2015. [PMID] 26683067.
2016
Respiratory outcomes after mid-cervical transplantation of embryonic medullary cells in rats with cervical spinal cord injury.
Experimental neurology. 278:22-6 [DOI] 10.1016/j.expneurol.2016.01.017. [PMID] 26808660.
2016
Transcriptome assessment of the Pompe (Gaa-/-) mouse spinal cord indicates widespread neuropathology.
Physiological genomics. 48(11):785-794 [DOI] 10.1152/physiolgenomics.00075.2016. [PMID] 27614205.
2015
Altered activation of the tibialis anterior in individuals with Pompe disease: Implications for motor unit dysfunction.
Muscle & nerve. 51(6):877-83 [DOI] 10.1002/mus.24444. [PMID] 25186912.
2015
Comparative impact of AAV and enzyme replacement therapy on respiratory and cardiac function in adult Pompe mice.
Molecular therapy. Methods & clinical development. 2 [DOI] 10.1038/mtm.2015.7. [PMID] 26029718.
2015
Correcting Neuromuscular Deficits With Gene Therapy in Pompe Disease.
Annals of neurology. 78(2):222-34 [DOI] 10.1002/ana.24433. [PMID] 25925726.
2015
Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures.
Journal of visualized experiments : JoVE. (105) [DOI] 10.3791/52527. [PMID] 26556530.
2015
Hypoxia triggers short term potentiation of phrenic motoneuron discharge after chronic cervical spinal cord injury.
Experimental neurology. 263:314-24 [DOI] 10.1016/j.expneurol.2014.10.002. [PMID] 25448009.
2015
Intermittent hypoxia and neurorehabilitation.
Journal of applied physiology (Bethesda, Md. : 1985). 119(12):1455-65 [DOI] 10.1152/japplphysiol.00235.2015. [PMID] 25997947.
2015
Midcervical neuronal discharge patterns during and following hypoxia.
Journal of neurophysiology. 113(7):2091-101 [DOI] 10.1152/jn.00834.2014. [PMID] 25552641.
2015
Peripheral nerve and neuromuscular junction pathology in Pompe disease.
Human molecular genetics. 24(3):625-36 [DOI] 10.1093/hmg/ddu476. [PMID] 25217571.
2015
Spinal interneurons and forelimb plasticity after incomplete cervical spinal cord injury in adult rats.
Journal of neurotrauma. 32(12):893-907 [DOI] 10.1089/neu.2014.3718. [PMID] 25625912.
2015
Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease By Ampakines
American Journal of Respiratory Cell and Molecular Biology. 53(3):326-335 [DOI] 10.1165/rcmb.2014-0374OC. [PMID] 25569118.
2014
Acid Alpha-Glucosidase Gene Replacement Therapy To the Diaphragm Remodels Ventilatory Function in Severe Pompe Disease
The FASEB's Journal. 28(1, S)
2014
Intraspinal transplantation and modulation of donor neuron electrophysiological activity.
Experimental neurology. 251:47-57 [DOI] 10.1016/j.expneurol.2013.10.016. [PMID] 24192152.
2014
Long-term facilitation of ventilation in humans with chronic spinal cord injury.
American journal of respiratory and critical care medicine. 189(1):57-65 [DOI] 10.1164/rccm.201305-0848OC. [PMID] 24224903.
2014
Rapid diaphragm atrophy following cervical spinal cord hemisection.
Respiratory physiology & neurobiology. 192:66-73 [DOI] 10.1016/j.resp.2013.12.006. [PMID] 24341999.
2014
Sustained correction of motoneuron histopathology following intramuscular delivery of AAV in pompe mice.
Molecular therapy : the journal of the American Society of Gene Therapy. 22(4):702-12 [DOI] 10.1038/mt.2013.282. [PMID] 24336173.
2014
Ventilatory long-term facilitation in humans.
American journal of respiratory and critical care medicine. 189(8):1009-10 [DOI] 10.1164/rccm.201401-0089LE. [PMID] 24735041.
2013
5-Ht2 Receptor Activation Modulates Phrenic Motor Output Following Chronic Cervical Spinal Cord Injury
The FASEB's Journal. 27
2013
Aav9 Vector Encoding Hgaa Improves Synaptic Pathology of the Neuromuscular Junction in Pompe Disease
Neuromuscular Disorders. 23(9-10) [DOI] 10.1016/j.nmd.2013.06.659.
2013
Absence of Secondary Phrenic Motoneuron (Phmn) Loss Following Lateralized Cervical Contusion
The FASEB's Journal. 27
2013
Ampakines Induce a Persistent Increase in Phrenic Motor Output in Rats With Cervical Spinal Cord Injury
The FASEB's Journal. 27
2013
Apnea Alters the Pattern of Intermittent Hypoxia-Induced Long Term Facilitation in Anesthetized Mice
The FASEB's Journal. 27
2013
Cervical Spinal Cord Injury Results in Reorganization of Respiratory Activity in the Medulla
Cell Transplantation. 22:894-895
2013
CrossTalk proposal: Mechanical ventilation-induced diaphragm atrophy is primarily due to inactivity.
The Journal of physiology. 591(21):5255-7 [DOI] 10.1113/jphysiol.2013.254680. [PMID] 24187073.
2013
Diaphragm and ventilatory dysfunction during cancer cachexia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(7):2600-10 [DOI] 10.1096/fj.12-222844. [PMID] 23515443.
2013
Diaphragm Pacing Augments Ventilatory Function in Pompe Disease
Molecular Genetics and Metabolism. 108(2) [DOI] 10.1016/j.ymgme.2012.11.232.
2013
Differential Effects of in Vivo Vs. Cell Culture Hypoxia On Neural Progenitor Cell Expansion and Differentiation
The FASEB's Journal. 27
2013
Increased Bilateral External Intercostal Emg Activity During Tracheal Occlusions (To) in Conscious Rats With Unilateral Cervical Spinal Cord Injury (C-Sci)
The FASEB's Journal. 27
2013
Intermittent Respiratory Stimulation With Doxapram Induces Phrenic Motor Plasticity
The FASEB's Journal. 27
2013
Intrapleural administration of AAV9 improves neural and cardiorespiratory function in Pompe disease.
Molecular therapy : the journal of the American Society of Gene Therapy. 21(9):1661-7 [DOI] 10.1038/mt.2013.96. [PMID] 23732990.
2013
Neural Progenitor Transplantation Improves Respiratory Function Following Cervical Contusion Injury in the Adult Rat
Cell Transplantation. 22
2013
Neuroanatomical Plasticity in the Rat Forelimb After Incomplete Cervical Spinal Cord Injury
Cell Transplantation. 22
2013
Phase I/II trial of adeno-associated virus-mediated alpha-glucosidase gene therapy to the diaphragm for chronic respiratory failure in Pompe disease: initial safety and ventilatory outcomes.
Human gene therapy. 24(6):630-40 [DOI] 10.1089/hum.2012.250. [PMID] 23570273.
2013
Phrenic motoneuron discharge patterns following chronic cervical spinal cord injury.
Experimental neurology. 249:20-32 [DOI] 10.1016/j.expneurol.2013.08.003. [PMID] 23954215.
2013
Phrenic Motoneuron Loss Following Lateralized Cervical Contusion
Cell Transplantation. 22:908-909
2013
Rebuttal from Scott K. Powers, Ashley J. Smuder, David Fuller and Sanford Levine.
The Journal of physiology. 591(21) [DOI] 10.1113/jphysiol.2013.261552. [PMID] 24187075.
2013
Repeated intravenous doxapram induces phrenic motor facilitation.
Experimental neurology. 250:108-15 [DOI] 10.1016/j.expneurol.2013.08.016. [PMID] 24013015.
2013
Retrograde Transynaptic Tracing of the Inspiratory Intercostal Circuitry Following Cervical Spinal Cord Injury in Rats
The FASEB's Journal. 27
2013
Schwann Cell Transplantation Enhances Diaphragm Recovery Following Cervical Spinal Cord Injury
Cell Transplantation. 22
2013
Selective Activation of Respiratory Thoracic Efferents in the Spinal Cord of the in Situ Rat Preparation
The FASEB's Journal. 27
2013
Serotonergic Innervation of Prephrenic Cervical Interneurons
Cell Transplantation. 22
2013
The Diaphragm Rapidly Increases Expression of Muscle Atrophy Genes Following Acute Cervical Spinal Cord Injury (Csci)
The FASEB's Journal. 27
2013
The impact of spinal cord injury on breathing during sleep.
Respiratory physiology & neurobiology. 188(3):344-54 [DOI] 10.1016/j.resp.2013.06.009. [PMID] 23791824.
2013
The respiratory neuromuscular system in Pompe disease.
Respiratory physiology & neurobiology. 189(2):241-9 [DOI] 10.1016/j.resp.2013.06.007. [PMID] 23797185.
2012
Cervical Interneuron Bursting During Hypoxia in Anesthetized Rats
The FASEB's Journal. 26
2012
Cervical Spinal Cord Injury Alters the Pattern of Inspiratory and Expiratory Neuronal Activity in the Rat Medulla
Cell Transplantation. 21(4)
2012
Chronically Impaired Diaphragm Function Following Lateralized Cervical Contusion in Adult Rat Spinal Cord
Cell Transplantation. 21(4):781-782
2012
Contribution of the spontaneous crossed-phrenic phenomenon to inspiratory tidal volume in spontaneously breathing rats.
Journal of applied physiology (Bethesda, Md. : 1985). 112(1):96-105 [DOI] 10.1152/japplphysiol.00690.2011. [PMID] 22033536.
2012
Forelimb Neuroplasticity Following Incomplete Cervical Spinal Cord Injury in Adult Rat
Cell Transplantation. 21(4)
2012
In vivo intermittent hypoxia elicits enhanced expansion and neuronal differentiation in cultured neural progenitors.
Experimental neurology. 235(1):238-45 [DOI] 10.1016/j.expneurol.2012.01.027. [PMID] 22366327.
2012
Increased Interneuronal Activity Following High Cervical Spinal Cord Injury in Adult Rats
Cell Transplantation. 21(4)
2012
Pulmonary C-fiber activation attenuates respiratory-related tongue movements.
Journal of applied physiology (Bethesda, Md. : 1985). 113(9):1369-76 [DOI] 10.1152/japplphysiol.00031.2012. [PMID] 22936725.
2012
Recovery of inspiratory intercostal muscle activity following high cervical hemisection.
Respiratory physiology & neurobiology. 183(3):186-92 [DOI] 10.1016/j.resp.2012.06.006. [PMID] 22705013.
2012
Respiratory function following bilateral mid-cervical contusion injury in the adult rat.
Experimental neurology. 235(1):197-210 [DOI] 10.1016/j.expneurol.2011.09.024. [PMID] 21963673.
2012
Retrograde gene delivery to hypoglossal motoneurons using adeno-associated virus serotype 9.
Human gene therapy methods. 23(2):148-56 [DOI] 10.1089/hgtb.2012.009. [PMID] 22693957.
2012
Spinal delivery of AAV vector restores enzyme activity and increases ventilation in Pompe mice.
Molecular therapy : the journal of the American Society of Gene Therapy. 20(1):21-7 [DOI] 10.1038/mt.2011.214. [PMID] 22008916.
2012
Synaptic Integration Between Transplanted Neural Progenitor Tissue and the Injured Adult Rat Spinal Cord
Cell Transplantation. 21(4)
2011
Anatomical Integration of Transplanted Neural Tissue Following Cervical Contusion Injury in Adult Rat
Cell Transplantation. 20
2011
Breathing patterns after mid-cervical spinal contusion in rats.
Experimental neurology. 231(1):97-103 [DOI] 10.1016/j.expneurol.2011.05.020. [PMID] 21683697.
2011
Functional Reorganization in the Medulla Following High Cervical Spinal Cord Injury
Cell Transplantation. 20
2011
Hypoglossal neuropathology and respiratory activity in pompe mice.
Frontiers in physiology. 2 [DOI] 10.3389/fphys.2011.00031. [PMID] 21747768.
2011
Neural control of phrenic motoneuron discharge.
Respiratory physiology & neurobiology. 179(1):71-9 [DOI] 10.1016/j.resp.2011.02.014. [PMID] 21376841.
2011
Plasticity in the Phrenic Motor System Following High Cervical Spinal Cord Injury in Adult Rats
Cell Transplantation. 20
2011
Pompe disease gene therapy.
Human molecular genetics. 20(R1):R61-8 [DOI] 10.1093/hmg/ddr174. [PMID] 21518733.
2011
Respiratory muscles and motoneurons.
Respiratory physiology & neurobiology. 179(1):1-2 [DOI] 10.1016/j.resp.2011.06.027. [PMID] 21762791.
2011
Sex differences in heart rate variability during sleep following prenatal nicotine exposure in rat pups.
Behavioural brain research. 219(1):82-91 [DOI] 10.1016/j.bbr.2010.12.013. [PMID] 21163307.
2010
Compensatory Activity in the Phrenic Motor System Following Cervical Spinal Cord Injury
Cell Transplantation. 19
2010
Gel-mediated delivery of AAV1 vectors corrects ventilatory function in Pompe mice with established disease.
Molecular therapy : the journal of the American Society of Gene Therapy. 18(3):502-10 [DOI] 10.1038/mt.2009.305. [PMID] 20104213.
2010
Hypoxia-induced short-term potentiation of respiratory-modulated facial motor output in the rat.
Respiratory physiology & neurobiology. 173(1):107-11 [DOI] 10.1016/j.resp.2010.06.015. [PMID] 20601212.
2010
Influence of vagal afferents on supraspinal and spinal respiratory activity following cervical spinal cord injury in rats.
Journal of applied physiology (Bethesda, Md. : 1985). 109(2):377-87 [DOI] 10.1152/japplphysiol.01429.2009. [PMID] 20507963.
2010
Neural Circuitry and Respiratory Neuroplasticity After Cervical Spinal Cord Injury (Sci) in the Adult Rat
Cell Transplantation. 19:346-347
2010
Neuronal progenitor transplantation and respiratory outcomes following upper cervical spinal cord injury in adult rats.
Experimental neurology. 225(1):231-6 [DOI] 10.1016/j.expneurol.2010.06.006. [PMID] 20599981.
2010
Phrenicotomy alters phrenic long-term facilitation following intermittent hypoxia in anesthetized rats.
Journal of applied physiology (Bethesda, Md. : 1985). 109(2):279-87 [DOI] 10.1152/japplphysiol.01422.2009. [PMID] 20395548.
2010
Preinspiratory and inspiratory hypoglossal motor output during hypoxia-induced plasticity in the rat.
Journal of applied physiology (Bethesda, Md. : 1985). 108(5):1187-98 [DOI] 10.1152/japplphysiol.01285.2009. [PMID] 20150564.
2010
The phrenic motor nucleus in the adult mouse.
Experimental neurology. 226(1):254-8 [DOI] 10.1016/j.expneurol.2010.08.026. [PMID] 20816820.
2010
Ventilatory Function Following Contusion in the Cervical Spinal Cord of Adult Rats
Cell Transplantation. 19
2009
Graded unilateral cervical spinal cord injury and respiratory motor recovery.
Respiratory physiology & neurobiology. 165(2-3):245-53 [DOI] 10.1016/j.resp.2008.12.010. [PMID] 19150658.
2009
Neural deficits contribute to respiratory insufficiency in Pompe disease.
Proceedings of the National Academy of Sciences of the United States of America. 106(23):9419-24 [DOI] 10.1073/pnas.0902534106. [PMID] 19474295.
2009
Phrenic motoneuron discharge patterns during hypoxia-induced short-term potentiation in rats.
Journal of neurophysiology. 102(4):2184-93 [DOI] 10.1152/jn.00399.2009. [PMID] 19657076.
2009
Prenatal nicotine exposure alters respiratory long-term facilitation in neonatal rats.
Respiratory physiology & neurobiology. 169(3):333-7 [DOI] 10.1016/j.resp.2009.09.015. [PMID] 19818419.
2009
Rapid Raav-Mediated Improvement of Respiratory Function in An Animal Model of Pompe Disease
Molecular Therapy. 17
2009
Recovery of airway protective behaviors after spinal cord injury.
Respiratory physiology & neurobiology. 169(2):150-6 [DOI] 10.1016/j.resp.2009.07.018. [PMID] 19635591.
2009
Respiratory recovery following high cervical hemisection.
Respiratory physiology & neurobiology. 169(2):94-101 [DOI] 10.1016/j.resp.2009.06.014. [PMID] 19560562.
2009
Spinal circuitry and respiratory recovery following spinal cord injury.
Respiratory physiology & neurobiology. 169(2):123-32 [DOI] 10.1016/j.resp.2009.08.007. [PMID] 19698805.
2008
Cervical prephrenic interneurons in the normal and lesioned spinal cord of the adult rat.
The Journal of comparative neurology. 511(5):692-709 [DOI] 10.1002/cne.21864. [PMID] 18924146.
2008
Characterization of Cellular Replacement Mediated Modulation of Respiratory Behavioral Neuroplasticity Following Cervical Spinal Cord Hemisection
Cell Transplantation. 17
2008
Could Interneurons Contribute To Respiratory Plasticity Following Cervical Spinal Cord Injury in Rat?
Cell Transplantation. 17
2008
Modest spontaneous recovery of ventilation following chronic high cervical hemisection in rats.
Experimental neurology. 211(1):97-106 [DOI] 10.1016/j.expneurol.2008.01.013. [PMID] 18308305.
2008
Pulmonary C-fiber receptor activation abolishes uncoupled facial nerve activity from phrenic bursting during positive end-expired pressure in the rat.
Journal of applied physiology (Bethesda, Md. : 1985). 104(1):119-29 [PMID] 17916674.
2008
Respiratory neuroplasticity and cervical spinal cord injury: translational perspectives.
Trends in neurosciences. 31(10):538-47 [DOI] 10.1016/j.tins.2008.07.002. [PMID] 18775573.
2008
Ventilation and phrenic output following high cervical spinal hemisection in male vs. female rats.
Respiratory physiology & neurobiology. 162(2):160-7 [DOI] 10.1016/j.resp.2008.06.005. [PMID] 18586119.
2007
Neural drive to tongue protrudor and retractor muscles following pulmonary C-fiber activation.
Journal of applied physiology (Bethesda, Md. : 1985). 102(1):434-44 [PMID] 16973814.
2007
Physiological correction of Pompe disease by systemic delivery of adeno-associated virus serotype 1 vectors.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(3):501-7 [PMID] 17245350.
2007
Uncoupling of upper airway motor activity from phrenic bursting by positive end-expired pressure in the rat.
Journal of applied physiology (Bethesda, Md. : 1985). 102(3):878-89 [PMID] 17082369.
2006
Long-term facilitation of ipsilateral but not contralateral phrenic output after cervical spinal cord hemisection.
Experimental neurology. 200(1):74-81 [PMID] 16647702.
2006
Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?
Respiratory physiology & neurobiology. 152(3):255-65 [PMID] 16723284.
2006
Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats.
Journal of applied physiology (Bethesda, Md. : 1985). 100(3):800-6 [PMID] 16269524.
2005
Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors.
Journal of neurotrauma. 22(2):203-13 [PMID] 15716627.
2005
Differences in time-dependent hypoxic phrenic responses among inbred rat strains.
Journal of applied physiology (Bethesda, Md. : 1985). 98(3):838-44 [PMID] 15531560.
2005
Episodic hypoxia induces long-term facilitation of neural drive to tongue protrudor and retractor muscles.
Journal of applied physiology (Bethesda, Md. : 1985). 98(5):1761-7 [PMID] 15640385.
2004
BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia.
Nature neuroscience. 7(1):48-55 [PMID] 14699417.
2004
Developmental plasticity of the hypoxic ventilatory response in rats induced by neonatal hypoxia.
The Journal of physiology. 557(Pt 2):645-60 [PMID] 15020695.
2003
Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia.
Journal of applied physiology (Bethesda, Md. : 1985). 95(3):946-52 [PMID] 12909596.
2003
Respiratory motor recovery after unilateral spinal cord injury: eliminating crossed phrenic activity decreases tidal volume and increases contralateral respiratory motor output.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(6):2494-501 [PMID] 12657710.
2003
Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(7):2993-3000 [PMID] 12684486.
2002
Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat.
Neuroscience letters. 323(1):25-8 [PMID] 11911982.
2002
Life-long impairment of hypoxic phrenic responses in rats following 1 month of developmental hyperoxia.
The Journal of physiology. 538(Pt 3):947-55 [PMID] 11826178.
2002
Respiratory-related activation of human abdominal muscles during exercise.
The Journal of physiology. 541(Pt 2):653-63 [PMID] 12042369.
2001
Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(14):5381-8 [PMID] 11438615.
2001
Effect of pulmonary stretch receptor feedback and CO(2) on upper airway and respiratory pump muscle activity in the rat.
The Journal of physiology. 532(Pt 2):525-34 [PMID] 11306669.
2001
Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat.
Physiological genomics. 4(3):175-81 [PMID] 11160996.
2001
Induced recovery of hypoxic phrenic responses in adult rats exposed to hyperoxia for the first month of life.
The Journal of physiology. 536(Pt 3):917-26 [PMID] 11691883.
2001
Invited review: Intermittent hypoxia and respiratory plasticity.
Journal of applied physiology (Bethesda, Md. : 1985). 90(6):2466-75 [PMID] 11356815.
2001
Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985). 90(5):2001-6; discussion 2000 [PMID] 11299296.
2001
Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapnia.
Respiration physiology. 129(1-2):25-35 [PMID] 11738644.
2001
Ventilatory long-term facilitation in unanesthetized rats.
Journal of applied physiology (Bethesda, Md. : 1985). 91(2):709-16 [PMID] 11457785.
2000
Fatiguing contractions of tongue protrudor and retractor muscles: influence of systemic hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985). 88(6):2123-30 [PMID] 10846026.
2000
Influence of posture and breathing route on neural drive to upper airway dilator muscles during exercise.
Journal of applied physiology (Bethesda, Md. : 1985). 89(2):590-8 [PMID] 10926642.
2000
Long term facilitation of phrenic motor output.
Respiration physiology. 121(2-3):135-46 [PMID] 10963770.
1999
Effect of co-activation of tongue protrudor and retractor muscles on tongue movements and pharyngeal airflow mechanics in the rat.
The Journal of physiology. 519 Pt 2(Pt 2):601-13 [PMID] 10457075.
1998
Co-activation of tongue protrudor and retractor muscles during chemoreceptor stimulation in the rat.
The Journal of physiology. 507 ( Pt 1)(Pt 1):265-76 [PMID] 9490849.
1996
Control of nasal dilator muscle activities during exercise: role of nasopharyngeal afferents.
Journal of applied physiology (Bethesda, Md. : 1985). 80(5):1520-7 [PMID] 8727535.
1996
Expiratory muscle endurance performance after exhaustive submaximal exercise.
Journal of applied physiology (Bethesda, Md. : 1985). 80(5):1495-502 [PMID] 8727532.
1995
Measurement of the EMG-force relationship in a human upper airway muscle.
Journal of applied physiology (Bethesda, Md. : 1985). 79(1):270-8 [PMID] 7559231.
Molecular and histologic outcomes following spinal cord injury in spiny mice,Acomys cahirinus
. [DOI] 10.1101/793133.

Grants

May 2024 ACTIVE
Fuller T32 renewal
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Apr 2024 ACTIVE
Spinal Direct Current Stimulation to Enhance Breathing Following Cervical Spinal Cord Injury
Role: Other
Funding: NATL INST OF HLTH NINDS
Jul 2023 ACTIVE
Direct Current Stimulation to Restore Breathing Following Spinal Cord Injury
Role: Other
Funding: PARKER B FRANCIS FELLOWSHIP FOU
Jul 2021 – Jul 2023
Ampakine mediated respiratory recovery following cervical spinal cord injury
Role: Other
Funding: CRAIG H NEILSEN FOU
Jul 2021 – Jun 2023
Role of an arousal circuit in respiration and opioid-induced respiratory depression
Role: Other
Funding: NATL INST OF HLTH NHLBI
Aug 2020 ACTIVE
Hyperbaric oxygen therapy mitigates respiratoryneuromuscular pathology after spinal cord injury
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
May 2020 ACTIVE
Control of Breathing and Pompe Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
May 2019 – Apr 2024
Interdisciplinary Training in Neuromuscular Plasticity and Rehabilitation
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Feb 2019 – Jan 2021
A new method of spinal stimulation TO activate the diaphragm
Role: Other
Funding: NATL INST OF HLTH NHLBI
Oct 2018 – Jun 2021
National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Pilot Projects Component
Role: Co-Investigator
Funding: UNIV OF ALABAMA BIRMINGHAM via NATL INST OF HLTH NICHD
Sep 2018 – Sep 2023
Acute Intermittent Hypoxia and Respiratory Strength Training to Improve Breathing Function after SCI
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2018 – Mar 2020
Phrenic Afferents and Neuromuscular Plasticity Following Spinal Cord Injury
Role: Other
Funding: NATL INST OF HLTH NHLBI
Aug 2018 – Jul 2021
Phrenic motoneuron activation using temporal interference
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2018 – Jun 2023
Ampakines and Respiratory Neuroplasticity
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Aug 2018 – Jul 2019
Phrenic afferents and neuromuscular plasticity following spinal cord injury
Role: Other
Funding: PARKER B FRANCIS FELLOWSHIP FOU
Jun 2018 – May 2020
A novel approach to activate paralyzed muscles following cervical spinal cord injury
Role: Principal Investigator
Funding: UF RESEARCH
Jul 2017 – Jul 2022
Electrical Stimulation and Intraspinal Transplantation
Role: Co-Investigator
Funding: CRAIG H NEILSEN FOU
Sep 2016 – Jul 2022
Functional mapping of peripheral and central circuits for airway protection and breathing
Role: Co-Investigator
Funding: NATL INST OF HLTH OD
Sep 2016 – Jan 2019
Diaphragm pacing and rehabilitation in Pompe disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Sep 2015 – Dec 2019
Intramuscular pacing to enhance voluntary diaphragm activation
Role: Project Manager
Funding: CRAIG H NEILSEN FOU
Dec 2014 – Jun 2017
Novel combinatorial approach to enhance host-graft connectivity
Role: Principal Investigator
Funding: CRAIG H NEILSEN FOU
Sep 2014 – Sep 2017
Plasticity and Activation of Spared Intraspinal Respiratory Circuits Following Spinal Cord Injury
Role: Project Manager
Funding: US DEPT OF DEFENSE
May 2014 – Apr 2019
DSR Matching – T32 Interdisciplinary Training
Role: Principal Investigator
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
May 2014 – Apr 2019
Interdisciplinary Training in Rehabilitation and Neuromuscular Plasticity
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Sep 2012 – Jun 2018
Control of Breathing and Pompe Disease
Role: Project Manager
Funding: NATL INST OF HLTH NICHD
May 2012 – Apr 2018
Modulation of Phrenic Motoneuron Plasticity after Cervical Spinal Cord Injury
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Dec 2011 – Jan 2018
Plasticity and Repair in the Phrenic Motor System
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Apr 2010 – Mar 2016
Automated Assessment of Structural Changes & Functional Recovery Post Spinal Injury using Diff
Role: Project Manager
Funding: NATL INST OF HLTH
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH

Education

Post-Doctoral Fellowship
1999-2002 · University of Wisconsin
PhD
1998 · University of Arizona
MS
1994 · University of Arizona
BS
1992 · Miami University

Contact Details

Phones:
Business:
(352) 273-6634
Emails:
Addresses:
Business Mailing:
UNIVERSITY OF FLORIDA
PO BOX 100154
DEPT. OF PHYSICAL THERAPY
GAINESVILLE FL 326100154
Business Street:
DEPT. OF PHYSICAL THERAPY
GAINESVILLE FL 32611